Format

Send to

Choose Destination
Arch Pediatr Adolesc Med. 2000 Dec;154(12):1214-8.

Treatment of sialorrhea with glycopyrrolate: A double-blind, dose-ranging study.

Author information

1
Shriners Hospital for Children, 1900 Richmond Rd, Lexington, KY 40502, USA. rjmier@aol.com

Abstract

OBJECTIVE:

To determine the safety and efficacy of glycopyrrolate in the treatment of developmentally disabled children with sialorrhea.

DESIGN:

Placebo-controlled, double-blind, crossover dose-ranging study.

SETTING:

Outpatient facilities in 2 pediatric hospitals.

PATIENTS:

Thirty-nine children with both developmental disabilities and excessive and bothersome sialorrhea.

MAIN OUTCOME MEASURES:

Parent and investigator evaluation of change in sialorrhea and adverse effects.

RESULTS:

Glycopyrrolate in doses of 0.10 mg/kg per dose is effective at controlling sialorrhea. Even at low doses, 20% of children may exhibit adverse effects severe enough to require discontinuation.

CONCLUSIONS:

Glycopyrrolate is effective in the control of excessive sialorrhea in children with developmental disabilities. Approximately 20% of children given glycopyrrolate may experience substantial adverse effects, enough to require discontinuation of medication. Arch Pediatr Adolesc Med. 2000;154:1214-1218.

PMID:
11115305
DOI:
10.1001/archpedi.154.12.1214
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center