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Oncogene. 2000 Nov 20;19(49):5558-67.

Connecting signaling and cell cycle progression in growth factor-stimulated cells.

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1
Schepens Eye Research Institute, 20 Staniford Street, Boston, Massachusetts, MA 02114, USA.

Abstract

A widely used model system to investigate cell proliferation is stimulation of serum-arrested cells with growth factors. Recent data suggest that there are two waves of growth factor-dependent signaling events required for a proliferative response. One is an acute burst of signaling, which occurs immediately after growth factor stimulation and lasts for 30 - 60 min. The other occurs in a different time frame (8 - 12 h post stimulation), and involves activation of cyclin dependent kinases (Cdks). In addition to a general overview of growth factor-dependent signaling, we present our 'two wave' hypothesis for how signaling and cell cycle progression are linked.

PMID:
11114735
DOI:
10.1038/sj.onc.1203858
[Indexed for MEDLINE]
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