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Curr Opin Struct Biol. 2000 Dec;10(6):744-52.

Trapping intermediates in the crystal: ligand binding to myoglobin.

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Max Planck Institute for Molecular Physiology, Department for Physical Biochemistry, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.


Crystal structures of the reactive short-lived species that occur in chemical or binding reactions can be determined using X-ray crystallography via time-resolved or kinetic trapping approaches. Recently, various kinetic trapping methods have been used to determine the structure of intermediates in ligand binding to myoglobin.

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