Format

Send to

Choose Destination
Curr Opin Struct Biol. 2000 Dec;10(6):656-61.

Structural basis of cell-cell interactions in the immune system.

Author information

1
Dana-Farber Cancer Institute and Department of Pediatrics and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. jwang@red.dfci.harvard.edu

Abstract

During the past year, advances in our understanding of receptor-ligand interactions between opposing cell surfaces have occurred at a structural level. These include adhesion involving CD2-CD58, antigen-specific T-cell receptor interactions with peptides bound to major histocompatibility complex molecules (both pMHCI and pMHCII), the CD8alphaalpha co-receptor-pMHCI interaction and the binding of two distinct classes of natural killer receptors to self-MHC ligands.

PMID:
11114502
DOI:
10.1016/s0959-440x(00)00150-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center