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Immunol Today. 2000 Dec;21(12):624-30.

Natural antibodies and complement link innate and acquired immunity.

Author information

1
Institute of Experimental Immunology, Switzerland. adrian.ochsenbein@insel.ch

Abstract

Natural or spontaneous antibodies are an essential part of the first line of defense against hematogenically spreading infections, including viruses. These antibodies target virus-antibody complexes and complement to the spleen. This prevents infections from reaching vital organs and enhances neutralizing antibody responses, particularly when the antibody is bound to a highly repetitive antigen.

PMID:
11114423
[Indexed for MEDLINE]

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