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Neurology. 2000 Dec 12;55(11):1730-2.

The pathology of REM sleep behavior disorder with comorbid Lewy body dementia.

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1
Veterans Administration Medical Center Geriatric Research Education and Clinical Center, Ann Arbor, MI 48105, USA. raymondt@umich.edu

Abstract

A patient with REM sleep behavior disorder who subsequently developed probable Lewy body dementia is now reported to have a definite pathologic diagnosis of Lewy body dementia. Examination of brain revealed Lewy bodies as well as marked neuronal loss in brainstem monoaminergic nuclei-particularly locus coeruleus and substantia nigra-that inhibit cholinergic neurons in the pedunculopontine nucleus mediating atonia during REM sleep.

PMID:
11113232
[Indexed for MEDLINE]
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