Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Med Microbiol. 2000 Oct;290(4-5):295-9.

Regulation of toxin and virulence gene transcription in Bacillus thuringiensis.

Author information

1
Unité de Biochimie Microbienne, Centre National de la Recherche Scientifique URA 2172, Institut Pasteur, Paris, France. lereclus@pasteur.fr

Abstract

Bacillus thuringiensis is a spore-forming bacterium well known for its insecticidal properties and its ability to produce a crystal inclusion during sporulation. The specific activity of B. thuringiensis against insect larvae is due to the crystal proteins (Cry proteins). Two different transcriptional mechanisms (dependent and independent of sporulation) are responsible for cry gene transcription during the stationary phase. In addition to these specific insecticidal toxins, B. thuringiensis produces potential virulence factors including haemolysins, degradative enzymes and enterotoxins. A pleiotropic regulator (PlcR) that activates the transcription of various genes encoding such extracellular proteins has been identified. Its expression at the onset of the stationary phase is dependent on the growth medium and is controlled by the transition state regulator, SpoOA.

PMID:
11111901
DOI:
10.1016/S1438-4221(00)80024-7
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center