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Biochim Biophys Acta. 2000 Dec 15;1529(1-3):126-35.

Oxysterol biosynthetic enzymes.

Author information

1
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235-9046, USA. david.russel@utsouthwestern.edu

Abstract

Oxysterols, herein defined as derivatives of cholesterol with a hydroxyl group on the side chain, play several roles in lipid metabolism. Members of this class regulate the expression of genes that participate in both sterol and fat metabolism, serve as substrates for the synthesis of bile acids, and are intermediates in the transfer of sterols from the periphery to the liver. Three abundant naturally occurring oxysterols are 24-hydroxycholesterol, 25-hydroxycholesterol, and 27-hydroxycholesterol. The cholesterol hydroxylase enzymes that synthesize each of these have been isolated over the last several years and their study has produced insight into the biology of oxysterols. This article focuses on the properties of these enzymes.

PMID:
11111082
DOI:
10.1016/s1388-1981(00)00142-6
[Indexed for MEDLINE]

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