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Mol Cell Biochem. 2000 Sep;212(1-2):5-9.

Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.

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Institute of Molecular Immunology, Department for Proteinbiochemistry, GSF M√ľnchen, Germany.


The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context- and position-specific function of CREB on complex genes.

[Indexed for MEDLINE]

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