Send to

Choose Destination
Med Pediatr Oncol. 2000 Dec;35(6):544-6.

Deletion of 11q23 is a frequent event in the evolution of MYCN single-copy high-risk neuroblastomas.

Author information

Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.



Deletions of the long arm of chromosome 11 are frequently identified in human neuroblastomas.


We screened 394 primary neuroblastomas and 52 tumor-derived cell lines with a panel of 11q and 11p polymorphic markers to determine the frequency of chromosome 11 allelic deletion, and to differentiate partial deletions of chromosome 11q (unb[11q] LOH) from whole chromosome loss.


Allelic deletion occurred most frequently at cytogenetic band 11q23 and was detected in 161 primary neuroblastomas (41%) and 18 cell lines (35%). Eighty-seven tumors (22%) had unb[11q] LOH with a heterogeneous distribution of deletion breakpoints. Unb[11q] LOH was highly correlated with age > 1 year at diagnosis (P = 0.008), stage 4 disease (P = 0.001), unfavorable Shimada histopathology (P < 0.001), and assignment to a high-risk therapeutic protocol (P < 0.001), and was inversely correlated with MYCN amplification (P = 0.018). Patients whose tumors showed unb[11q] LOH were less likely to survive (P < 0.001), but there was only a trend towards an independent prognostic influence in multivariate analyses.


Thus, structural rearrangements resulting in unb[11q] LOH commonly occur during the malignant evolution of high-risk neuroblastomas with single-copy MYCN.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center