Format

Send to

Choose Destination
Curr Opin Immunol. 2000 Dec;12(6):676-83.

The role of different subsets of T regulatory cells in controlling autoimmunity.

Author information

1
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via Olgettina 58, Milan 20132, Italy. m.roncarolo@hsr.it

Abstract

T regulatory cells-in addition to clonal deletion and anergy-are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.

PMID:
11102772
DOI:
10.1016/s0952-7915(00)00162-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center