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Curr Opin Immunol. 2000 Dec;12(6):670-5.

Present difficulties and future promise of MHC multimers in autoimmune exploration.

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  • 1Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol├ęculaire et Cellulaire, 660 Route des Lucioles, 06560 Valbonne, France.

Abstract

Class I tetramers have been used to track cytotoxic T cells during bacterial and viral infections. During the past year, the use of such molecules has revealed important information about the role of CD8(+) T cells in autoimmune diabetes. Furthermore, class II multimers have been produced and successfully used to stain autoreactive CD4(+) T cells from patients with rheumatoid arthritis or Borrelia-burgdorferi-induced Lyme arthritis.

PMID:
11102771
[PubMed - indexed for MEDLINE]
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