Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Immunol. 2000 Dec;12(6):670-5.

Present difficulties and future promise of MHC multimers in autoimmune exploration.

Author information

  • 1Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol├ęculaire et Cellulaire, 660 Route des Lucioles, 06560 Valbonne, France.


Class I tetramers have been used to track cytotoxic T cells during bacterial and viral infections. During the past year, the use of such molecules has revealed important information about the role of CD8(+) T cells in autoimmune diabetes. Furthermore, class II multimers have been produced and successfully used to stain autoreactive CD4(+) T cells from patients with rheumatoid arthritis or Borrelia-burgdorferi-induced Lyme arthritis.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center