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Curr Opin Immunol. 2000 Dec;12(6):624-31.

Roles of mast cells and basophils in innate and acquired immunity.

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Department of Pathology, L-235, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.


There have been several recent advances in knowledge about mast cells and basophils in immune responses, of which some are particularly important: a role has been found for heparin in the storage of certain proteases and other mediators in mast cell cytoplasmic granules; an important role for mast cells in the development of several chronic aspects of an asthma model in mice has been discovered; and a new approach has been developed, based on the generation of mast cells from embryonic stem cells in vitro, to investigate mast cell function in vitro or in vivo.

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