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Phys Rev Lett. 2000 Dec 11;85(24):5242-5.

Multiple-sequence information provides protection against mis-specified potential energy functions in the lattice model of proteins

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Department of Biostatistics, Harvard University, Boston, Massachusetts 02115 and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.


The neutral nets in the lattice models of proteins are composed of a group of similar sequences that encode for the same native structure. The maximal neutral nets in an HP and an AB lattice model are investigated by exhaustive enumeration in the conformation space. The result demonstrates that the performance of mis-specified potential functions can be improved significantly by averaging over sequences in the neutral nets.

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