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Nat Immunol. 2000 Dec;1(6):521-5.

Immune suppression and skin cancer development: regulation by NKT cells.

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Department of Immunology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA.


Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.

[Indexed for MEDLINE]

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