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Hepatogastroenterology. 2000 Sep-Oct;47(35):1371-4.

Surgical complications and long-term outcome in pediatric liver transplantation.

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1
Queensland Liver Transplant Service, Royal Children's Hospital, Brisbane, Australia.

Abstract

BACKGROUND/AIMS:

Liver transplantation has been widely accepted for the treatment of children with end-stage liver disease over the last 10 years particularly with the advent of reduced-size liver transplant technique. This study reviewed the perioperative and long-term results in the pediatric program of the Queensland Liver Transplant Service, Brisbane, Australia.

METHODOLOGY:

Retrospective analysis was performed in 153 children who received 176 liver grafts between 1985 and 1995, including 109 (62%) reduced-size and 67 (38%) whole liver grafts. Median follow-up period was 5.3 years.

RESULTS:

One-, 5-, and 10-year patient and graft survival rates were 82% and 74%, 75% and 63%, and 70% and 60%, respectively. Normal physical and intellectual development was observed in 98% of survivors. There were no significant differences in patient or graft survival rates between transplants using reduced-size and whole liver grafts. Portal vein thrombosis was the most common vascular complication, occurring in 8%. Hepatic artery thrombosis occurred in 7%, including 11% of children less than 1 year old and 8% of those under 10 kg. Biliary complication was found in 16% and posttransplant gastrointestinal perforation in 19%.

CONCLUSIONS:

Liver transplantation has the potential to cure and allow development in children with end-stage liver disease.

PMID:
11100354
[Indexed for MEDLINE]
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