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Depress Anxiety. 2000;12 Suppl 1:45-9.

Antidepressant efficacy of venlafaxine.

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Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599-7160, USA.


Venlafaxine is a unique antidepressant medication with well documented efficacy and safety in the acute treatment of major depressive disorder. Reports suggest that it may also be effective in the treatment of dysthymic disorder and bipolar II depression, but the available data for these conditions are more limited compared to major depressive disorder. Several studies suggest that there may be a more rapid onset of action for venlafaxine in the treatment of major depression compared to other antidepressant pharmacotherapies, but this has not been fully established. Venlafaxine is also effective in the important long term continuation and maintenance phases of the treatment of depression.

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