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Breast Cancer Res Treat. 2000 Sep;63(2):147-52.

Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells.

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Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA.


Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.

[Indexed for MEDLINE]

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