Acute renal failure: unusual complication of Epstein-Barr virus-induced infectious mononucleosis

Clin Infect Dis. 2000 Dec;31(6):1519-24. doi: 10.1086/317497.

Abstract

A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / virology
  • Adolescent
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Infectious Mononucleosis / complications*
  • Infectious Mononucleosis / virology
  • Kidney / pathology
  • Kidney / virology
  • Male
  • Nephritis, Interstitial / pathology
  • Nephritis, Interstitial / virology
  • RNA, Viral / analysis
  • RNA, Viral / genetics

Substances

  • Epstein-Barr virus encoded RNA 1
  • RNA, Viral