Format

Send to

Choose Destination
Arthritis Res. 2000;2(3):189-202. Epub 2000 Apr 12.

Macrophages in rheumatoid arthritis.

Author information

1
Experimental Rheumatology Unit, Friedrich Schiller University, Jena, Germany. Raimund.W.Kinne@rz.uni-jena.de

Abstract

The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if not as antigen-presenting cells in early disease), macrophages possess widespread pro-inflammatory, destructive, and remodeling capabilities that can critically contribute to acute and chronic disease. Also, activation of the monocytic lineage is not locally restricted, but extends to systemic parts of the mononuclear phagocyte system. Thus, selective counteraction of macrophage activation remains an efficacious approach to diminish local and systemic inflammation, as well as to prevent irreversible joint damage.

PMID:
11094428
PMCID:
PMC130001
DOI:
10.1186/ar86
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center