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Immunol Today. 2000 Nov;21(11):584-91.

Lymphocytes with a complex: adapter proteins in antigen receptor signaling.

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Dept of Medicine and the Howard Hughes Medical Institute, University of California at San Francisco, CA 94143-0795, USA.


Adapters can be defined as proteins that mediate intermolecular interactions within a signal transduction pathway and that lack both intrinsic enzymatic and transcriptional activity. Their essential role in lymphocyte signaling was revealed by recent analyses of mice and cell lines deficient in LAT, SLP-76 and BLNK. These and other adapters nucleate signaling complexes and facilitate coupling of antigen receptor triggering to functional responses in lymphocytes.

[Indexed for MEDLINE]

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