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Immunol Today. 2000 Nov;21(11):567-73.

Protein kinase Ctheta: a new essential superstar on the T-cell stage.

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Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.


Recent studies have identified protein kinase Cθ (PKCtheta), a member of the Ca(2+)-independent PKC family, as an essential component of the T-cell synapse that cooperates with calcineurin to activate the interleukin-2 (IL-2) gene. Several selective functions of PKCtheta involved in the activation and survival of T cells are reviewed herein. Among these, the nuclear factor-kappaB (NF-kappaB) signaling cascade appears to be the most critical target of PKCtheta in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation.

[Indexed for MEDLINE]

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