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Immunol Today. 2000 Nov;21(11):561-6.

Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe.

Author information

1
University of Washington, Dept of Immunology, Seattle, WA 98195, USA. pfink@u.washington.edu

Abstract

Pamela Fink and Catherine McMahan discuss how B and T cells test for useful antigen receptors and weed out potentially harmful ones, with special attention paid to T-cell receptor revision, a newly described mechanism by which mature T cells can maintain self tolerance.

PMID:
11094260
DOI:
10.1016/s0167-5699(00)01734-5
[Indexed for MEDLINE]

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