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Neurology. 2000 Nov 28;55(10):1572-5.

Menstrual-related changes in motoric function in women with Parkinson's disease.

Author information

1
Department of Neurological Sciences, Rush-Presbyterian-St Luke's Medical Center, Rush University, Chicago, IL, USA. kkompoli@rush.edu

Abstract

Questionnaire studies have found that parkinsonism worsens in women during the premenstrual period, when estrogen and progesterone levels are presumably at their nadir. To assess this patient-based observation and correlate motor signs with hormonal levels, the authors prospectively studied 10 menstruating women with PD in their "off" state, on 5 successive weeks. Although PD severity fluctuated during the study period, there was no significant correlation between the objective or subjective measures of parkinsonism and estrogen and progesterone levels.

PMID:
11094119
[Indexed for MEDLINE]
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