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J Med Chem. 1979 May;22(5):483-91.

Multivariate analysis and quantitative structure-activity relationships. Inhibition of dihydrofolate reductase and thymidylate synthetase by quinazolines.


Quantitative structure-activity relationships (QSAR) have been established for the inhibition of dihydrofolate reductase and thymidylate synthetase by 2,4-diaminoquinazoline-glutamic acid analogues. For dihydrofolate reductase from both human acute lymphocytic leukemia cells and murine L1210R cells, QSAR's obtained with 50 quinazolines were similar. On the other hand, for the inhibition of thymidylate synthetase from murine L1210S cells and from Lactobacillus casei, QSAR's formulated on the basis of data measured with 33 compounds were different, indicating that the two enzymes are dissimilar. The use of multivariate statistics including cluster analysis, factor analysis, and discriminant analysis is shown to facilitate the formulation of a satisfactory correlation equation. The procedure is demonstrated by the development of QSAR for the inhibition of thymidylate synthetase.

[PubMed - indexed for MEDLINE]
J Wildl Dis. 1979 Jan;15(1):51-3.

Sarcocystis in free-ranging herbivores on the National Bison Range.


Heart, esophagus, diaphragm and skeletal muscle obtained from various herbivores on the National Bison Range were examined grossly for Sarcocystis. Sarcocystis was found in 81, 50, 50, and 13% of the mule deer, (Odocoileus hemionus), white-tailed deer (O. virginianus), elk (Cervus elaphus), and bison (Bison bison), respectively.

[PubMed - indexed for MEDLINE]

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