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Annu Rev Genet. 2000;34:653-686.

Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come.

Author information

1
Hypnion Inc, Five Biotech, 381 Plantation Street, Worcester, Massachusetts 01605, USA. kjm@hypnion.aol.com

Abstract

In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse (). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.

PMID:
11092842
DOI:
10.1146/annurev.genet.34.1.653
[Indexed for MEDLINE]

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