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Cell Mol Life Sci. 2000 Oct;57(11):1517-25.

Localization and stabilization of ionotropic glutamate receptors at synapses.

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Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA.


Appropriate targeting and clustering of ionotropic glutamate receptors (iGluRs) is critical for the formation and maintenance of excitatory synapses. Recent studies have demonstrated that the synaptic localization of iGluR subtypes is remarkably heterogeneous and subject to regulation over time scales ranging from minutes to months. These findings, together with the identification of key protein binding partners of iGluRs, have opened a window onto the complex cell biology of iGluR membrane trafficking. In this article, we review recent findings on the cellular and molecular mechanisms involved in localizing iGluRs at synapses and discuss their implications for synaptogenesis and synaptic plasticity.

[Indexed for MEDLINE]

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