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Headache. 2000 Oct;40(9):736-9.

Treatment of chronic daily posttraumatic headache with divalproex sodium.

Author information

1
Department of Neuropsychiatry, Texas Tech University, Lubbock 79430, USA.

Abstract

OBJECTIVE:

To determine the effectiveness of divalproex sodium in the treatment of chronic daily posttraumatic headaches.

BACKGROUND:

Divalproex sodium has been found to be useful for the treatment of migraine and chronic daily headache. No studies have been done to evaluate effectiveness in posttraumatic headache.

METHODS:

A retrospective review was done of 100 patients treated with divalproex for chronic daily posttraumatic headache of 2 months or longer.

RESULTS:

Sixty percent of patients with chronic posttraumatic headache had mild to moderate improvement in their headaches after at least 1 month of divalproex sodium. Forty percent either showed no response (26%) or discontinued treatment because of side effects (14%). Fifty-eight percent of patients showing improvement had a change in headache pattern from daily to episodic.

CONCLUSIONS:

Divalproex sodium appears to be safe and effective for treatment of patients with persistent, chronic daily posttraumatic headaches.

PMID:
11091292
[Indexed for MEDLINE]

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