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Plant Mol Biol. 2000 Aug;43(5-6):583-93.

Regulation of cyclin-dependent kinases in Arabidopsis thaliana.

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Department Plantengenetic, Vlaams Interuniversitair Instituut voor Biotechniologie, Universiteit Gent, Belgium.


In plants, different families of cyclin-dependent kinases (CDKs) and cyclins have been identified, indicating that also in plants the progression through the cell cycle is regulated by CDKs. In all eukaryotes, CDKs exert their activity through well-controlled phosphorylations of specific substrates on serine/threonine residues. Such post-translational modifications are universal mechanisms in signal transduction pathways. They allow the organism to differentiate, regulate growth and/or adapt to environmental changes, the latter being crucial for plants because of their sedentary life-style. This adaptation might explain the occurrence of a special CDK type with plant-specific features. This review focuses on the involvement of plant CDKs in different phases of the cell cycle in Arabidopsis thaliana and outlines their regulation by binding to other proteins, and by phosphorylation and dephosphorylation.

[Indexed for MEDLINE]

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