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Curr Opin Genet Dev. 2000 Dec;10(6):656-61.

Compositional bias in DNA.

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Biometry and Evolutionary Biology Laboratory (bâtiment 741), Université Claude Bernard Lyon 1 and CNRS, 43 bd 11 nov, 69622 Villeurbanne Cedex, France.


Experimental approaches, as well as computer analysis on genomic sequences, have revealed a large variability in base composition between regions in the same genome or between genomes of different species. In most cases, however, the biological causes of these compositional biases remain unknown. The recent large increase in the availability of completely sequenced genomes can give new insight into evolution processes involved in these compositional biases.

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