Send to

Choose Destination
See comment in PubMed Commons below
Arch Dis Child. 2000 Dec;83(6):498-501.

Unlicensed and off label prescribing of drugs in general practice.

Author information

  • 1Academic Division of Child Health (University of Nottingham), Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3NE, UK.



To determine the incidence and nature of unlicensed and off label prescribing of drugs for children in general practice.


A retrospective analysis of all prescriptions for one year involving children (aged 12 years or under) from a single suburban general practice in the English Midlands. Prescribed drugs were categorised as licensed, unlicensed (without a product licence), or used in an off label way (outside the terms of their product licence).


During 1997 there were 3347 prescription items involving 1175 children and 160 different drugs. A total of 2828 (84. 5%) prescriptions were for licensed medicines used in a licensed way; 10 (0.3%) were for unlicensed medicines; and 351 (10.5%) were licensed medicines used in an off label way. For 158 (4.7%) the information was insufficient to determine licence status.


This is the first study to show that a significant number of drugs prescribed for children by general practitioners are off label and highlights the anomalies and inadequacies of drug information for prescribers.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center