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Trends Biochem Sci. 2000 Nov;25(11):544-8.

Ubiquitin in chains.

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Dept of Biochemistry and Molecular Biology, School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.


The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation. Recent results have revealed important determinants of polyubiquitin-chain recognition by proteasomes, helping to explain the biological rationale behind this novel signaling mechanism.

[Indexed for MEDLINE]

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