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Mol Cell Neurosci. 2000 Nov;16(5):529-41.

Doublecortin-like kinase is associated with microtubules in neuronal growth cones.

Author information

1
Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel.

Abstract

Doublecortin-like kinase (DCLK) shares sequence similarity to Doublecortin (DCX) in its N-terminal region. It contains the evolutionary conserved DC repeat motif as well a C-terminal kinase domain. Ectopic expression of DCLK in COS cells results in colocalization with microtubules, and phosphorylated DCLK copurifies with microtubules during assembly from embryonic brain extract. During brain development DCLK is expressed mainly in postmigratory neurons in a similar pattern to DCX. We demonstrate that DCLK is a microtubule-associated active protein kinase expressed in growth cones of postmitotic neurons.

PMID:
11083916
DOI:
10.1006/mcne.2000.0891
[Indexed for MEDLINE]

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