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J Cardiovasc Electrophysiol. 2000 Nov;11(11):1277-80.

Infant case with a malignant form of Brugada syndrome.

Author information

1
Department of Pediatrics, Nagaoka Red Cross Hospital, Nagaoka, Japan.

Abstract

We report a 6-month-old Japanese infant with a malignant form of Brugada syndrome, who had frequent episodes of ventricular fibrillation (VF) and nonsustained polymorphic ventricular tachycardia (VT). To the best of our knowledge, this infant is the youngest patient reported to have Brugada syndrome. Continuous infusion of a beta-adrenergic agonist and intravenous injection of a parasympathetic antagonist suppressed the electrical storm of polymorphic VT and VF. Combined oral administration of a beta1-adrenergic agonist, a parasympathetic antagonist, and quinidine has successfully suppressed recurrences of VT or VF for 6 months, and the combination may have the potential to decrease the incidence of VT or VF as an adjunctive therapy with prophylactic placement of an implantable cardioverter defibrillator.

PMID:
11083249
[Indexed for MEDLINE]

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