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Bioorg Med Chem Lett. 2000 Nov 6;10(21):2457-61.

N-[1-(2-Phenylethyl)pyrrolidin-3-yl]-1-adamantanecarboxamides as novel 5-HT2 receptor antagonists.

Author information

1
Exploratory Research I, Drug Discovery Laboratories, Welfide Corporation, Iruma, Saitama, Japan. fujio@welfide.co.jp

Abstract

A series of 1-adamantanecarboxamides was synthesized and examined for their potency as a selective 5-HT2 receptor antagonist. We found (S)-N-[1-[2-(4-fluorophenyl)ethyl]pyrrolidin-3-yl]-1-adamantane carboxamide hydrochloride hydrate (10-(S), Y-39241) to have a high affinity and selectivity for 5-HT2 receptors, and this potent anti-platelet effect of Y-39241 was confirmed both in vitro and in vivo.

PMID:
11078200
DOI:
10.1016/s0960-894x(00)00492-3
[Indexed for MEDLINE]

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