Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex

S Bani; A Kaul; B S Jaggi; K A Suri; O P Suri; O P Sharma

doi:10.1016/s0367-326x(00)00225-2

Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex

Fitoterapia. 2000 Dec;71(6):655-62. doi: 10.1016/s0367-326x(00)00225-2.

Authors

S Bani¹, A Kaul, B S Jaggi, K A Suri, O P Suri, O P Sharma

Affiliation

¹ Department of Pharmacology, Regional Research Laboratory, Canal Road, Jammu, India.

PMID: 11077172
DOI: 10.1016/s0367-326x(00)00225-2

Abstract

The hydrosoluble fraction of Euphorbia royleana latex (AER), administered by gavage at doses of 50-200 mg/kg, showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It reduced the exudate volume and the migration of leukocytes and showed a poor inhibitory effect on the granuloma formation induced by cotton pellets, while it had a low ulcerogenic score. The oral LD(50) was more than 1500 mg/kg in both rats and mice.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Arthritis / drug therapy*
Disease Models, Animal
Dose-Response Relationship, Drug
Edema / drug therapy*
Euphorbiaceae*
Hindlimb / drug effects
Latex / chemistry
Latex / pharmacology
Latex / therapeutic use*
Leukocytes / drug effects*
Male
Mice
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Rats
Stomach Ulcer / prevention & control*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Latex
Plant Extracts