Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Otolaryngol Head Neck Surg. 2000 Nov;126(11):1359-62.

Fewer symptoms occur in same-serotype recurrent streptococcal tonsillopharyngitis.

Author information

1
Food and Drug Administration, Division of Vaccines and Related Product Applications, HFM 475, Suite 370N, 1401 Rockville Pike, Rockville, MD 20852, USA.

Abstract

BACKGROUND:

Most patients with acute rheumatic fever report no antecedent pharyngitis.

OBJECTIVE:

To determine the clinical and microbiological characteristics of recurrent group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis.

DESIGN:

Prospective randomized trial.

SUBJECTS:

Symptoms were recorded and throat cultures were obtained at 4 to 6, 18 to 21, and 32 to 35 days following the start of treatment. A subset of 60 patients with subsequent GABHS episodes occurring were evaluated for a 0.2-or greater log rise in either antistreptolysin O or anti-deoxyribonuclease B titer to confirm a bona fide recurrence.

RESULTS:

Sixteen (27%) of 60 patients had recurrent GABHS tonsillopharyngitis of the same serotype that occurred 21 days or longer following the onset of the initial GABHS infection and was associated with a 0.2- or greater log rise in either antistreptolysin O or anti-deoxyribonuclease B titer, indicating bona fide recurrent infection; these recurrences all occurred within 55 days. Fewer patients with recurrent GABHS pharyngitis of the same serotype had headache (P =.02), sore throat (P =.006), fever (P =. 008), pharyngeal erythema (P<.001), pharyngeal edema (P<.001), pharyngeal exudate (P =.04), and adenitis (P =.03) compared with the initial episode. Chills, stomachache, scarlatina, tonsillar enlargement, and palatal petechiae were similar for both episodes.

CONCLUSIONS:

Fewer symptoms occur during recurrent GABHS pharyngitis of the same serotype compared with the initial infection. These patients may be less likely to seek physician attention, yet their infections put them at risk for sequelae.

PMID:
11074833
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center