Format

Send to

Choose Destination
Trends Neurosci. 2000 Nov;23(11):580-7.

Kainate, a double agent that generates seizures: two decades of progress.

Author information

1
The INMED, INSERM U29, Parc scientifique de Luminy, BP 13, 13273, Marseille, France.

Abstract

Studies using kainate, an excitatory amino acid extracted from a seaweed, have provided major contributions to the understanding of epileptogenesis. Here we review pioneering and more recent studies aimed at determining how kainate generates seizures and, in particular, how inhibition is altered during seizures. We focus on target and subunit-specific effects of kainate on hippocampal pyramidal neurons and interneurons that lead to an excitation of both types of neurons and thus to the parallel increase of glutamatergic and GABAergic spontaneous currents. We propose that kainate excites all its targets, the net consequence depending on the level of activity of the network.

PMID:
11074268
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center