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Lancet. 2000 Oct 7;356(9237):1241-2.

Lithium-induced increase in human brain grey matter.

Erratum in

  • Lancet 2000 Dec 16;356(9247):2104. Menji HK [corrected to Manji HK].


Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.

[Indexed for MEDLINE]

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