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Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):919-22.

Pancreatic tumors show high levels of hypoxia.

Author information

1
Department Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA. akoong@cmgm.stanford.edu

Abstract

PURPOSE:

Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors.

METHODS AND MATERIALS:

Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode.

RESULTS:

All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation.

CONCLUSION:

Tumor hypoxia exists within pancreatic cancers.

PMID:
11072146
DOI:
10.1016/s0360-3016(00)00803-8
[Indexed for MEDLINE]

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