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Neurosci Lett. 2000 Nov 24;294(3):163-6.

Dynamics of mu-rhythm suppression caused by median nerve stimulation: a magnetoencephalographic study in human subjects.

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BioMag Laboratory, Medical Engineering Centre, Helsinki University Central Hospital, P.O. Box 442, FIN-00029 HUS, Helsinki, Finland.


We studied event-related desynchronization (ERD) of the 8-13 Hz rhythm (mu rhythm) of the primary somatosensory cortex (SI) caused by contra- and ipsilateral median-nerve stimulation. We used whole-head magnetoencephalography (MEG) and wavelet analysis together with our newly developed color-coded single-trial ERD display. The somatosensory stimuli suppressed mu rhythm at both contra- and ipsilateral SI, but the attenuation was clearly lateralized, being at least 20% stronger contra- than ipsilaterally. Moreover, repeated stimulation significantly reduced mu-rhythm ERD in the ipsilateral but not in the contralateral hemisphere in the course of the experiment. The observed lateralization is in agreement with the classical concept of a dominant role of the contralateral hemisphere in the processing of somatosensory information. The strong ipsilateral ERD in the beginning of the experiment may reflect the presence of non-specific arousal-like activation, which attenuates toward the end of the experiment.

[Indexed for MEDLINE]

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