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Nucleic Acids Res. 2000 Nov 15;28(22):4474-8.

Wild-derived inbred mouse strains have short telomeres.

Author information

1
Predoctoral Training Program in Human Genetics and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains. We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.

PMID:
11071935
PMCID:
PMC113886
[Indexed for MEDLINE]
Free PMC Article

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