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Neurology. 2000 Oct 24;55(8):1096-1100.

Panayiotopoulos-type benign childhood occipital epilepsy: a prospective study.

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  • 1Hospital Nacional de Pediatria Juan P. Garrahan, Buenos Aires, Argentina.



To characterize the clinical and EEG features of the syndrome of benign childhood partial seizures with ictal vomiting and EEG occipital spikes (Panayiotopoulos syndrome [PS]).


Prospective study of children with normal general and neurologic examinations who had seizures with ictal vomiting and EEG with occipital spikes.


From February 1990 to 1997, the authors found 66 patients with PS and 145 children with benign childhood epilepsy with centrotemporal spikes. Peak age at onset of PS was 5 years. Ictal deviation of the eyes and progression to generalized seizures were common. One-third had partial status epilepticus. During sleep, all had seizures. While awake, one-third also had seizures. Five children with PS had concurrent symptoms of rolandic epilepsy and another five developed rolandic seizures after remission of PS. Prognosis was excellent: one-third had a single seizure, one-half had two to five seizures, and only 4.5% had frequent seizures.


Panayiotopoulos-type benign childhood occipital epilepsy is less common than benign childhood epilepsy with centrotemporal spikes but is well defined and recognizable by clinical and EEG features.

[PubMed - indexed for MEDLINE]
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