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Appl Biochem Biotechnol. 2000 Oct;89(1):67-83.

Retrofit of CD-6 (Smith) impeller in fermentation vessels.

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Bioprocess Research and Development, Merck Research Laboratories, Rahway, NJ 07065, USA.


We extended prior studies on the influence of impeller type on fermentation performance to include a novel low-power-number, high-efficiency radial flow impeller, the CD-6, possessing six curved blades on a disk turbine. Dual impeller combinations of CD-6/CD-6, CD-6/Maxflo T, and CD-6/HE-3 were compared with Rushton/Rushton and Maxflo T/Maxflo T base cases. Qualitative comparisons of unaerated and aerated power draw in both water and glycerol were conducted. These suggested minimal power drops with aeration for dual CD-6 impellers and hybrids containing the CD-6 impeller design. We also examined fermentation performance for Streptomyces and Glarea secondary metabolite fermentations. A qualitative comparison of the data suggested that dual CD-6 impellers and hybrids containing the CD-6 impeller design resulted in reasonable power draws, improved mass transfer rates with airflow increases, and acceptable peak titers. These arrangements may warrant further study under a wider range of production conditions.

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