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Peptides. 2000 Oct;21(10):1561-3.

Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK.

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Department of Medicine, Burns & Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.


We tested the hypothesis that the release of PYY by fat confined to the proximal small intestine is dependent on CCK. Using a multi-fistulated model, plasma PYY levels were compared in 6 dogs after 60 mM oleate was perfused into the proximal one-half of the small intestine following i.v. administration of saline or devazepide, a CCK-A antagonist. Plasma PYY increased with fat (P < 0. 05), but plasma PYY level was lower following devazepide at 60 min and 90 min (P < 0.05). We conclude that CCK serves as a foregut signal linking fat in the proximal gut with the release of distal gut PYY.

[Indexed for MEDLINE]

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