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Cell Biol Int. 2000;24(11):799-802.

S100-annexin complexes: some insights from structural studies.

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LURE (CNRS, CEA, MENRT), Centre Universitaire Paris-Sud, Orsay, 91898, France.


Several annexins have been shown to bind proteins that belong to the S100 calcium-binding protein family. The two best-characterized complexes are annexin II with p11 and annexin I with S100C, the former of which has been implicated in membrane fusion processes. We have solved the crystal structures of the complexes of p11 with annexin II N-terminus and of S100C with annexin I N-terminus. Using these structural results, as well as electron microscopy observations of liposome junctions formed in the presence of such complexes (Lambert et al., 1997 J Mol Biol 272, 42-55), we propose a computer generated model for the entire annexin II/p11 complex.

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