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Curr Opin Cell Biol. 2000 Dec;12(6):676-84.

Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle.

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Department of Oncology/Pathology, Cancer Center Karolinska, Karolinska Insitutet, 17176, Stockholm, Sweden.


Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.

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