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Arthritis Res. 2000;2(2):142-4. Epub 2000 Feb 24.

Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue.

Author information

1
St Vincent's University Hospital, Dublin, Ireland.

Abstract

Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA expression was confirmed in all samples obtained from patients with RA, but not in normal synovium. A-SAA mRNA expression was also demonstrated in cultured RA synoviocytes. A-SAA protein was identified in the supernatants of primary synoviocyte cultures, and its expression colocalized with sites of macrophage accumulation and with some vascular endothelial cells. It is concluded that A-SAA is produced by inflamed RA synovial tissue. The known association between the acute-phase response and progressive joint damage may be the direct result of synovial A-SAA-induced effects on cartilage degradation.

PMID:
11062604
PMCID:
PMC17807
DOI:
10.1186/ar78
[Indexed for MEDLINE]
Free PMC Article

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