Format

Send to

Choose Destination
Nat Med. 2000 Nov;6(11):1229-34.

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo.

Author information

1
StemCells, 525 Del Rey Avenue, Suite C, Sunnyvale, California 94085, USA. elagasse@stemcell.net

Abstract

The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH(-/-) mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional assumptions of the germ layer origins of tissues such as the liver, and raises the question of whether the cells of the hematopoietic stem cell phenotype are pluripotent hematopoietic cells that retain the ability to transdifferentiate, or whether they are more primitive multipotent cells.

Comment in

PMID:
11062533
DOI:
10.1038/81326
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center