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Nat Immunol. 2000 Nov;1(5):379-85.

Antibody regulation of B cell development.

Author information

1
Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA.

Abstract

Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Ig alpha and Ig beta. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.

PMID:
11062496
DOI:
10.1038/80816
[Indexed for MEDLINE]

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